Circadian Pharmacokinetics
Baojian Wu, Danyi Lu, Dong Dong
This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
Categorías:
Año:
2020
Edición:
1
Editorial:
Springer
Idioma:
english
Páginas:
260
ISBN 10:
9811588074
ISBN 13:
9789811588075
Archivo:
PDF, 6.11 MB
IPFS:
,
english, 2020
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